Regulation of autophagy by plant‐based polyphenols: A critical review of current advances in glucolipid metabolic diseases and food industry applications

Autophagy is a complex self-degrading process, and its imbalance adversely affects local (metabolically active organs) or systemic metabolism, resulting in metabolic dysfunction correlated with obesity, fatty liver, type 2 diabetes. Polyphenols are plant secondary metabolites their ingestion may offer beneficial effects on biological processes, including cell proliferation, cycle, apoptosis autophagy. In this review, the of plant-based polyphenols autophagy underlying mechanisms regulation glucolipid diseases (GLMDs) examined context potential health benefits. The available evidence, mainly from animal models, strongly supports that improve functions different organs by acting various molecular targets related to autophagic flux. Multiple pathways, cAMP, AMPK, MAPK, AKT, SIRT1, PI3K, Nrf2/HO-1, PINK1/Parkin, PPARδ, miRNAs have been implicated improvement GLMDs polyphenols. Moreover, utilization polyphenol-meditated food industry was discussed. current review provides comprehensive understanding prospective role polyphenol-regulated opens up future insights into application healthcare industries.